Intracellular Uncoating of Type 5 Adenovirus Deoxyribonucleic Acid
نویسندگان
چکیده
منابع مشابه
Adenovirus type 5 pseudotyped with adenovirus type 37 fiber uses sialic acid as a cellular receptor.
For purposes of gene therapy, the tropism of adenovirus (Ad) serotype 5 vectors can be altered with fibers derived from alternative serotypes. However, there is currently limited information available on the cellular receptors used by the approximately 51 known Ad serotypes. Recently, alpha(2-->3)-linked sialic acid (2,3-SA) has been implicated as the cellular receptor for wild-type Ad37. Howev...
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After infection of Escherichia coli B with radiolabeled T7 bacteriophage, the parental deoxyribonucleic acid label was found in both polynucleotide chains of the intracellular T7 concatemer.
متن کاملStructure of Type 5 Adenovirus
Type 5 adenovirus was purified by fluorocarbon (freon 113) treatment followed by banding in a CsCl equilibrium density gradient. This method permitted separation of virus from normal host cell materials and virus-specific soluble antigens. Virus banded in CsCl with a mean bouyant density of 1.3349 gm/cm(3). The three virus-specific soluble antigens (group- and type-specific antigens and toxin) ...
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HeLa cell cultures infected with adenovirus type 4 were studied by light and phase-contrast microscopy and by the fluorescent antibody technique for visualization of intracellular antigen. The findings were correlated with the growth curve of infectious virus, determined from companion cultures. The results indicated that those cells undergoing characteristic structural changes observable by li...
متن کاملHelper-dependent infectious deoxyribonucleic acid from adenovirus-associated virus.
The defectiveness of adenovirus-associated viruses (AAV) is now well known (1, 8, 9, 11). Adenoviruses from widely divergent phylogenetic hosts, including man and monkeys (1), dogs (8), mice (M. D. Hoggan and N. R. Blacklow, unpublished data), and chickens (4) can serve as helpers for the formation of AAV in cell cultures. Furthermore, in the human host AAV replication is apparently dependent u...
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ژورنال
عنوان ژورنال: Journal of Virology
سال: 1967
ISSN: 0022-538X,1098-5514
DOI: 10.1128/jvi.1.5.851-867.1967